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KMID : 0370220070510010063
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Yakhak Hoeji
2007 Volume.51 No. 1 p.63 ~ p.67
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Relationship Between Histamine Release and Ca2+ Mobilization in RBL 2H3 Mast Cells
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Park Sung-Hun
Kim Soo-Jeong
Kim Jung-Min
Park Ju-Hyun
Choi Bang-Shil
Lee Ji-Yun
Choi Mi-Yeong
Sim Sang-Soo
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Abstract
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To investigate the relation between extracellular Ca2+ and histamine release, we observed agonist-induced histamine release from RBL 2H3 mast cells in the presence or absence of extracellular Ca2+ concentration. Histamine release induced by melittin and thapsigargin were greater in the presence of extracellular Ca2+ than in the absence of extracellular Ca2+. Econazole-induced histamine release had nothing to do with extracellular Ca2+, whereas arachidonic acid-induced histamine release increased in the absence of extracellular Ca2+. Calmodulin antagonists did not affect melittin-induced histamine release but they may potentiate arachidonic acid-induce histamine release. These data suggest that arachidonic acid-induced histamine release may be mediated via Ca2+ -independent pathway and may be potentiated by the block of Ca2+ -dependent pathway.
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KEYWORD
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mast cells, histamine, calcium, calmodulin antagonist
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